23 drug efflux one of the most studied mechanisms of cancer drug resistance involves reducing drug accumulation by enhancing efflux members of the atp binding cassette abc transporter family proteins enable this efflux and are important well studied regulators at the plasma membranes of healthy cells. One of the main causes of failure in the treatment of cancer is the development of drug resistance by the cancer cells this is a very serious problem that may lead to recurrence of disease or even death this section is intended to introduce some of the main ways in which cancer cells can resist treatments. The cells of most patients cancers are resistant to a class of drugs called proteasome inhibitors that should kill them when studied in the lab these drugs are highly effective yet hundreds . The ability for cancer cells to develop resistance to chemotherapy drugs known as multi drug resistance remains a leading cause for tumor recurrence and cancer metastasis but recent . Cancer chemotherapy resistance mdr is the innate and or acquired ability of cancer cells to evade the effects of chemotherapeutics and is one of the most pressing major dilemmas in cancer therapy chemotherapy resistance can arise due to several host or tumor related factors however most current research is focused on tumor specific factors and specifically genes that handle expression of
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