Despite the advantages stem cell therapy is still limited by low survival engraftment and homing to damage area as well as inefficiencies in differentiating into fully functional tissues genetic engineering of mesenchymal stem cells is being explored as a means to circumvent some of these problems. Bone marrow stromal cells mesenchymal stem cells are used for several purposes 1 to engineer for sustained in vivo protein secretion 2 to enhance retroviral mediated gene transduction into hematopoietic stem cells 3 as a feeder layer to maintain 45 ja nolta ed genetic engineering of mesenchymal stem cells 45 58 c 2006 springer. Msc mesenchymal stem cells have been reported to initiate revascularization after injury to facilitate engraftment of blood forming stem cells and to reduce the incidence of graft vs host disease through their immune suppressive qualities. Mesenchymal stem cell engineering and transplantation f aerts and g wagemaker establishment and transduction of primary human stromal mesenchymal stem cell monolayers t meyerrose i rosova m dao p herrbrich g bauer and j nolta gene expression profiles of mesenchymal stem cells dg phinney in vivo homing and regeneration . Abstract mesenchymal stem cells mscs are very attractive for regenerative medicine due to their relatively easy derivation and broad range of differentiation capabilities either naturally or induced through cell engineering
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