Nonsteroidal anti inflammatory drugs nsaids are a drug class that reduce pain decrease fever prevent blood clots and in higher doses decrease inflammation side effects depend on the specific drug but largely include an increased risk of gastrointestinal ulcers and bleeds heart attack and kidney disease. Pdf non steroidal anti inflammatory drugs nsaids are a group of often chemically unrelated compounds with some common therapeutic actions and side effects they have potent anti inflammatory . Basic clinical pharmacology 11th ed new york mcgraw hill 2009 pp 313 330 yaksh t l dirig d m malmberg a b mechanism of action of nonsteroidal anti inflammatory drugs cancer invest 1998 16 7509 527 wallace j l cirino g the development of gastrointestinal sparing nonsteroidal anti inflammatory drugs. 0001 nonsteroidal anti inflammatory drugs are some of the most prolifically prescribed and prolifically used drugs in the world 0009 they are used in inflammation and for pain they also may be used for a mild anti fever or antipyretic effect and theyve been used to inhibit polyp formation in patients who have familial adenomatous polyp. The principal molecular mechanisms underlying the cardiovascular cv and renal adverse effects of nonsteroidal anti inflammatory drugs nsaids such as myocardial infarction and hypertension are understood in more detail than most side effects of drugs
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